Covid-19

Asintomáticos: ¿test o no test? Esa es la cuestión Resulta fácil entender que desde que una persona se infecta pasa a ser una fuente de contagio. Lo realmente difícil es saber saber quién es una fuente y quién no, más aún cuando entran en juego personas que, sin siquiera ellos saberlo, están infectadas.  Si todos …

GISTs

English What are GISTs? GIST stands for “Gastrointestinal stromal tumour”, since they were thought to be originated from the stroma. However, now we know that the pacemaker cells of the gastrointestinal muscularis propria, called cells of Cajal, are the real origin of this tumour. Cells of Cajal: Their immunophenotype is from both smooth muscle and …

Melanoma

English Introduction: Melanoma is a malignant neoplasm derived from melanocytes, the skin cells that produce melanin, constituting the most deadly of all skin cancers. Location: * Information henceforward will be about cutaneous melanoma. Clinical signs: The following signs increase the clinical suspicion of melanoma: Pathogenesis: Stages: Microscopic aspects: Cells: Shape: polygonal cells: most frequently spindle …

Summarizing “Pathology of Perineural Spread”

  English Introduction This post is a summary of “Pathology of perineural spread”, a paper from the Queensland Pathology department (Australia).   It is well known that tumour cells can metastasize through blood and lymphatic vessels (the most common pathways). However, there are more ways cancers can spread beyond their primary site and one is …

Papillary Thyroid Carcinoma

English Introduction In this post we're showing you a Papillary Thyroid Carcinoma case: one of the differentiated primary carcinomas of the thyroid gland that accounts for 85 % of all thyroid carcinomas. Due to the propensity to invade lymphatics within thyroid, this neoplasm is usually multifocal and gives metastases through lymphatic vessels to adjacent lymph …

Multinodular goiter

In this post we show you gross , cytology and biopsy pictures of a multinodular goiter case

Barret Esophagus.

English Pathogenesis In order to understand Barret esophagus we should first focus on Gastroesophageal Reflux Disease (GERD), since Barret Esophagus is a complication of chronic GERD. So... what is GERD? GERD is the disorder affecting the lower esophageal sphincter (LES), causing heartburn and acid indigestion. This two symptoms are because of the stomach contents going …

Terminology of interest in Pathology

English In this post we show you the meaning of different terms in order to know how to correctly use them. Español  En este post te mostramos una lista con el significado de diferentes términos, para poder usarlos correctamente.

Devil Facial Tumour Disease (DFTD)

English Today's post is not about humans, but Tasmanian Devils: a carnivorous marsupial which is facing extinction. But... why? Because of a tumour: Devil Facial Tumour Disease (DFTD). Let's meet the Tasmanian Devil To begin, we should know how a healthy Tasmanian Devil looks like... ...in comparison with a diseased one:  Tumour features Affected areas …

Hepatocellular adenoma: molecular approach

English Hepatocellular adenoma, as its noun suggests, is a benign tumour developed from the hepatocytes. From a molecular point of view, three subtypes have been identified: HNF1-α Inactivated hepatocellular adenomas, β-Catenin Activated hepatocellular adenomas and inflammatory hepatocellular adenomas. *Althought they all are defined as bening tumours, its potential of malignant transformation (in different risk grades for each …