English Introduction Some posts ago we talked about HER-2 (HER2 overexpression: core info), but we’re going over it again in order to add information about its implications in GEAs (gastroesophageal adenocarcinomas). HER-2 in gastric cancer Gastric adenocarcinoma Gastric adenocarcinoma accounts for approximately 90–95% of all stomach cancers, with lymphoma, leiomyosarcoma, gastrointestinal stromal tumor and neuroendocrine … Continue reading HER-2 amplification in gastric cancer
Category: Genes
Ki67
What is Ki67? Learn it here!
Gene Expression Profiles for Early Stage Lung Adenocarcinoma
Español De acuerdo con la última guía ESMO para el manejo de carcinoma pulmonar de célula no pequeña (CPCNP) en estadios tempranos, se debe ofrecer quimioterapia adyuvante a todos los pacientes en estadio II, III. No debe valorarse en pacientes con enfermedad IA y, podría ser útil en pacientes con estadiaje IB y factores de … Continue reading Gene Expression Profiles for Early Stage Lung Adenocarcinoma
HER2 overexpression: core info
English What is HER2? HER2 is a transmembrane receptor with intrinsic tyrosine kinase activity. It belongs to the superfamily of epidermal growth factor receptors. Overexpression of HER2 can lead to unabated kinase activity through either autodimerization or proteolysis. Literature: Robbins and Cotran. Pathologic basis of disease. 9. Canada: Elsevier; 2015.
Angiogenesis: core information
From a molecular point of view, angiogenesis is produced by an increased production of angiogenic factors and/or loss of angiogenic inhibitors. The following list shows the main involded factors: HIF1α p53 VEGF Literature: Robbins and Cotran. Pathologic basis of disease. 9. Canada: Elsevier; 2015.
miRNAs (II): how do they function?
English How do miRNAs function from a molecular point of view? miRNAs silence gene expression, but... how? Accelerating mRNA degradation (A) and repressing translation (B). A. Accelerating mRNA degradation We must focus on Argonaute family protein (AGO) since they bind to miRNA in order to form the basic core of miRNA-induced silencing complexes (miRISCs): miRNAs + … Continue reading miRNAs (II): how do they function?
miRNAs (I): introduction
English In this post we're introducing miRNAs in order to focus on their role in cancer disease in coming posts. Thus, today we're sharing basic information: Next post → miRNAs (II): how do they function?
Main APP mutations related with Alzheimer’s disease familial type 1 early-onset
English Main APP mutations related with Alzheimer’s disease familial type 1 early-onset Alzheimer’s disease (AD) is a neurodegenerative illness which belongs to amyloidosis diseases and which produces the atrophy of the cerebral cortex causing dementia and decrease of the intelligence. The protein that causes the deposit of amyloid is the APP (Amyloid Precursor Protein), a … Continue reading Main APP mutations related with Alzheimer’s disease familial type 1 early-onset
MGMT promoter methylation: focusing on Glioblastoma
English This gene encodes a DNA repair enzyme that catalyzes transfer of methyl groups in order to repair toxicity. Main trigger factors are alkylating agents [1], which form covalent bonds with nucleophilic substances in the DNA [2] and potentially lead to cell death through halting cell division [1]. Thus, methylation of the gene promoter has … Continue reading MGMT promoter methylation: focusing on Glioblastoma
Gene expression analysis in breast cancer samples. Endopredict optimization.
English Poster Session III CEIBS – Granada, March 2017 Title: Gene expression analysis in breast cancer samples. Endopredict optimization. Author: Isabel Betancor Fernández Tutor: Dr. Eduardo Salido Introduction: Spanish breast cancer screening programs have increased early stage carcinoma detection. Hormonal treatment in monotherapy might be considered a valid treatment option in luminal A/B type tumors. … Continue reading Gene expression analysis in breast cancer samples. Endopredict optimization.
Patólogos sin fronteras 