EGFR

English The Epidermal Growth Factor Receptor gene (EGFR) encodes a transmembrane glycoprotein, which belongs to the protein kinase superfamily. The protein binds to epidermal growth factors by the following mechanism: EFGR binds to the ligand Dimerization of the receptor and tyrosine autophosphorylation take place Cell proliferation occurs The mutation in exons 18, 19, 20 and 21 (which encode …

BRCAness in breast cancer

English Breast cancer constitutes the neoplasm of highest incidence, prevalence and mortality among women in western countries. Around 25-30% of these tumors are estrogen receptor (ER), progesterone receptor (PR) and HER2 negative. These tumors are called triple negative breast cancer (TNBC). TNBCs frequently appear in young patients. Familial aggregation is common. They showa high histological …